NFL Week 1 Picks, Predictions Against the Spread: NFL odds for 16-game slate

After what felt like an eternity, real NFL football will grace our television sets in less than 24 hours. With a full 16-game slate this week, here are our NFL Week 1 picks and predictions against the spread for each matchup. We found the NFL Week 1 odds at Sports Betting Dime and are accurate as of September 9 at 9 AM ET.

Week 1 NFL picks and predictions | Betting lines and NFL odds

After a few months off, there is a fervor around the return of the NFL. With sports betting becoming more and more widespread and legal across the United States, there has never been as much discussion around NFL picks, predictions, and odds. The NFL has even decided to openly embrace the world of gambling, with odds being added to their ticker this year and dedicated betting segments. Below, you can see the live lines at some of the most respected sportsbooks across the country.

Thursday night NFL picks and predictions

Here are the Week 1 betting lines and NFL odds for Thursday’s game.

Dallas Cowboys at Tampa Bay Buccaneers (-7.5)

Time and Channel: 8:20 PM ET, NBC

We touched on how much intrigue surrounded the return of the NFL this year — and in terms of questions and storylines — there might not have been a better matchup to kick off the regular season. The Dallas Cowboys will travel to Tampa Bay to take on the Super Bowl champion Buccaneers. Tom Brady and the Bucs are laying 7.5 at home.

Now, a lot of pundits have already decided that the Cowboys have little chance against a stacked Tampa Bay team that is basically returning all of their players from 2020.

That might be the case, but Dallas shouldn’t be the pushover it was last year. They now have one of the deepest linebacker units in the NFL and will see the return of their franchise QB in Dak Prescott.

The Cowboys have always played Tampa Bay close, leading the all-time series 13-4. These are two very different teams in 2021, but I think Dallas keeps it close and is able to eke out a close win under the bright lights of Thursday Night Football.

NFL Week 1 Picks and Predictions: Cowboys 34, Tampa Bay 31

Sunday NFL picks and predictions against the spread

Here are the NFL Week 1 betting lines, predictions, and odds for Sunday’s games.

Philadelphia Eagles at Atlanta Falcons (-3)

Time and Channel: 1 PM ET, FOX

These two teams have significant questions surrounding them. The Eagles are heading into the season with Jalen Hurts under center and Gardner Minshew as the QB3 behind Joe Flacco. Atlanta will look completely different offensively after trading WR Julio Jones in the offseason and drafting TE Kyle Pitts.

Without knowing what these teams will look like in 2021, I am taking the squad with fewer questions surrounding them. Matt Ryan and the Falcons’ offense should be able to score enough to win this one.

NFL Week 1 Picks and Predictions: Falcons 24, Eagles 14

Pittsburgh Steelers at Buffalo Bills (-6.5)

Time and Channel: 1 PM ET, CBS

The Buffalo Bills are entering the season as legitimate Super Bowl contenders for the first time in decades. With Josh Allen continuing to take leaps forward in his progression as a franchise QB, the hype makes sense. The Steelers have lost key weapons on their offensive line, and their QB is now one year older. The Bills start their Super Bowl run with a win at home.

NFL Week 1 Picks and Predictions: Bills 28, Steelers 23

Minnesota Vikings (-3.5) at Cincinnati Bengals

Time and Channel: 1 PM ET, FOX

Joe Burrow returns from a serious leg injury to take on the Vikings at home. Cincinnati’s biggest issue last year was their offensive line. Luckily, they’re playing the team with the worst pass rush from 2020. The Bengals might not be perfect, but I have faith Burrow will be able to throw all over this defense with no pressure coming his way — outside of a healthy Danielle Hunter, that is.

NFL Week 1 Picks and Predictions: Bengals 24, Vikings 21

San Francisco 49ers (-7) at Detroit Lions

Time and Channel: 1 PM ET, FOX

The 49ers are laying a touchdown on the road against the Detroit Lions. The Lions are in the talks for the worst team in the NFL, with Jared Goff now at the helm. I don’t think they are going to be as bad as everyone thinks, and I don’t like laying a TD on the road with any team. Take the Lions to cover.

NFL Week 1 Picks and Predictions: 49ers 21, Lions 16

Arizona Cardinals at Tennessee Titans (-3)

Time and Channel: 1 PM ET, CBS

The Tennessee Titans are also competing to be one of the best teams in the NFL. Their offense, on paper, is one of the best in the league with Derrick Henry, A.J. Brown, and now Julio Jones. If Ryan Tannehill remains healthy, the Titans will be one of the best teams in the league.

NFL Week 1 Picks and Predictions: Titans 28, Cardinals 20

Seattle Seahawks (-2.5) at Indianapolis Colts

Time and Channel: 1 PM ET, FOX

There are way too many questions surrounding the Colts and who will be healthy for this one. Is Carson Wentz going to play? Is he fully healthy at this point? Just take Russell Wilson and trust Seattle in this one.

NFL Week 1 Picks and Predictions: Seahawks 23, Colts 17

Los Angeles Chargers (-1) at Washington Football Team

Time and Channel: 1 PM ET, CBS

This is one of the most intriguing matchups of Week 1. Making a pick or prediction for this one is tough, with one of the most electric offenses in the league playing one of the best defenses. Washington being at home gives them the edge here.

NFL Week 1 Picks and Predictions: Washington 20, Chargers 19

New York Jets at Carolina Panthers (-5.5)

Time and Channel: 1 PM ET, CBS

This is an interesting one. Sam Darnold will be playing his former team as the new QB under center for the Panthers. Zach Wilson is now the guy in New York and has a new head coach with him. Will that be enough for him to win his first NFL game on the road? Probably not. Take Matt Rhule and the experience of the Panthers to get this win.

NFL Week 1 Picks and Predictions: Panthers 24, Jets 17

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Jacksonville Jaguars (-3) at Houston Texans

Time and Channel: 1 PM ET, CBS

This is probably one of the worst matchups of Week 1. With so many questions surrounding these two squads, any sort of NFL pick or prediction would be a complete guess. Trevor Lawrence is now the undisputed QB1 in Jacksonville after they traded away Minshew to the Eagles. The Texans are heading into the game with Tyrod Taylor at QB with the Deshaun Watson saga still surrounding the team. Flip a coin.

NFL Week 1 Picks and Predictions: Jaguars 17, Texans 14

Cleveland Browns at Kansas City Chiefs (-6)

Time and Channel: 4:25 PM ET, CBS

In another marquee matchup in Week 1, the Browns play the Super Bowl losers from last year in the Kansas City Chiefs. The Browns have one of the best defenses in the league right now, and the Chiefs one of the best offenses. Which will prevail in this one?

For my NFL picks and predictions, I am going with offense over defense. I do think that the Browns are playoff contenders — potentially even Super Bowl contenders — but the Chiefs and Mahomes are hard to bet against. This will be a high-scoring affair, with the Chiefs coming out on top.

NFL Week 1 Picks and Predictions: Chiefs 30, Browns 27

Miami Dolphins at New England Patriots (-2.5)

Time and Channel: 4:25 PM ET, CBS

This matchup was already intriguing when it was a simple AFC East showdown. However, with the Patriots deciding to cut Cam Newton, this game became even more exciting. Now, we get to see two former Alabama QBs square off when Tua Tagovailoa takes on Mac Jones.

Tua had an up-and-down first season with Miami but comes into this game the clear QB1. Jones has looked good in preseason, but this will be his first real NFL action. Miami’s defense is an elite unit, and I expect them to cause issues for Jones, who might have some first-game jitters to get over.

NFL Week 1 Picks and Predictions: Dolphins 24, Patriots 20

Green Bay Packers (-4.5) at New Orleans Saints

Time and Channel: 4:25 PM ET, Local

The Packers and Saints game is going to be a fireworks show. Both offenses should be able to exploit their opponent’s weak secondaries and put up points. With Jameis Winston at QB, the Saints should be able to move the ball downfield. Aaron Rodgers will look to prove that he still deserves to be in the best QB in the league discussion. This one should be fun.

NFL Week 1 Picks and Predictions: Packers 34, Saints 27

Denver Broncos (-3) at New York Giants

Time and Channel: 4:25 PM ET, FOX

Unfairly, this game could end up being rather left out of the limelight alongside the other three on this slate. The Broncos named Teddy Bridgewater as the starter, and he is the ideal QB for this talented roster. The Giants made some big moves in the offseason, but I’m not sure it leads to anything in Week 1.

NFL Week 1 Picks and Predictions: Broncos 20, Giants 17

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Chicago Bears at Los Angeles Rams (-7)

Time and Channel: 8:20 PM ET, NBC

Two exceptional defenses will be showcased during the Bears and Rams Sunday Night Football game. Look for a low-scoring game where the Rams come out on top.

NFL Week 1 Picks and Predictions: Rams 21, Bears 10

Monday night Week 1 NFL picks and predictions

Here are the NFL Week 1 betting lines, predictions, and odds for Monday’s game.

Baltimore Ravens (-4.5) at Las Vegas Raiders

Time and Channel: 8:15 PM ET, ESPN

To finish off the Week 1 slate of games, the Ravens take on the Raiders. On paper, the Ravens are the better team here, but I don’t think the Raiders’ home-field advantage is being given enough credit. Las Vegas will have a full house for the first time ever in their new stadium, and the crowd should give the Raiders the boost they need to get the win here.

NFL Week 1 Picks and Predictions: Raiders 27, Ravens 20

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